RNAi Sprays (RNA Interference)

Tier B — Program Tool Caution Biotechnology

Quick Facts

Type
Biotechnology
Source
Double-stranded RNA (dsRNA) molecules designed to silence essential genes in target insect species
OMRI Listed
No
Bee Safe
Yes
Pet Safe
Yes
Residual
Short — dsRNA degrades in UV and soil within days
Best For
Future of species-specific pest control. Colorado potato beetle is the first major target.

What Is RNAi Sprays (RNA Interference)?

dsRNA molecules are ingested by target insects and trigger the RNA interference pathway, silencing genes essential for survival. The insect's own cellular machinery destroys its own messenger RNA, shutting down critical proteins. Species-specific: only affects insects with the matching gene sequence.

Source: Double-stranded RNA (dsRNA) molecules designed to silence essential genes in target insect species

What Pests Does RNAi Sprays (RNA Interference) Kill?

RNAi Sprays (RNA Interference) is effective against the following pests:

How to Apply RNAi Sprays (RNA Interference)

Best for: Future of species-specific pest control. Colorado potato beetle is the first major target.

Avoid for: Current commercial use (limited availability). Budget-conscious operations.

Residual activity: Short — dsRNA degrades in UV and soil within days

Safety Profile

CategoryRating
Bee Safety 🟢 Safe for bees
Pet Safety 🟢 Safe for pets
Overall Rating Caution — Use with caution — timing and technique matter

Why Isn't RNAi Sprays (RNA Interference) Working?

If RNAi Sprays (RNA Interference) isn't delivering results, check these common failure modes:

dsRNA degrades rapidly in field conditions

Very few commercial products available yet

Regulatory frameworks still developing

Production cost currently high

Best RNAi Sprays (RNA Interference) Products

Calantha (GreenLight Biosciences)

Spray

First EPA-registered dsRNA insecticide — Colorado potato beetle